Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives

Eur J Med Chem. 2012 Sep:55:137-45. doi: 10.1016/j.ejmech.2012.07.012. Epub 2012 Jul 20.

Abstract

30 novel compounds have been synthesized from 25-hydroxyprotopanaxadiol (25-OH-PPD) and their in vitro anti-tumor activities were tested on three cancer cell lines and one normal cell line (IOSE144) by standard MTT assay. The results showed that compound 27 exhibited the best anti-tumor activity in the in vitro assays. Compounds 1, 2, 16, 17, 18, 27, 28 and 29 have better anti-tumor activities against MCF-7 and A549 cancer cell lines than 25-OH-PPD, together with low toxicity in the normal cell. The results may provide useful data for researching and developing new antitumor agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Chemistry Techniques, Synthetic
  • Ginsenosides / chemical synthesis*
  • Ginsenosides / chemistry
  • Ginsenosides / pharmacology*
  • Humans
  • Inhibitory Concentration 50

Substances

  • 25-hydroxyprotopanaxadiol
  • Antineoplastic Agents
  • Ginsenosides