Maintaining poise: commensal microbiota calibrate interferon responses

Jeremy P McAleer; Jay K Kolls

doi:10.1016/j.immuni.2012.07.001

Maintaining poise: commensal microbiota calibrate interferon responses

Immunity. 2012 Jul 27;37(1):10-2. doi: 10.1016/j.immuni.2012.07.001.

Authors

Jeremy P McAleer¹, Jay K Kolls

Affiliation

¹ Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.

PMID: 22840839
DOI: 10.1016/j.immuni.2012.07.001

Abstract

The mechanisms of how commensal bacteria impact systemic immunity are unclear. In this issue of Immunity, Abt et al. (2012) and Ganal et al. (2012) demonstrate that microbiota poise macrophages for induction of the type I interferon pathway after virus infection.

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