Abstract
We investigated chloroquine sensitivity to Plasmodium falciparum in travelers returning to France and Canada from Haiti during a 23-year period. Two of 19 isolates obtained after the 2010 earthquake showed mixed pfcrt 76K+T genotype and high 50% inhibitory concentration. Physicians treating malaria acquired in Haiti should be aware of possible chloroquine resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Animals
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Antimalarials / pharmacology
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Antimalarials / therapeutic use
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Canada / epidemiology
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Child
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Child, Preschool
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Chloroquine / pharmacology*
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Chloroquine / therapeutic use
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Disasters
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Drug Resistance / genetics*
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Earthquakes*
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Female
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France / epidemiology
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Genotype
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Haiti
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Humans
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Infant
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Malaria, Falciparum / drug therapy
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Malaria, Falciparum / parasitology
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Male
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Membrane Transport Proteins / genetics
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Middle Aged
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / genetics
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Plasmodium falciparum / isolation & purification
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Protozoan Proteins / genetics
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Travel*
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Young Adult
Substances
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Antimalarials
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Membrane Transport Proteins
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PfCRT protein, Plasmodium falciparum
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Protozoan Proteins
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Chloroquine