Abstract
XMRV and polytropic MLV-related virus have been controversially associated with chronic fatigue syndrome (CFS). Subsequent reports failed to detect XMRV and MLV-related virus in CFS patients, and the previous results have been interpreted as a massive laboratory contamination by mouse DNA sequences. Among 12 sequential CFS patients, two were positive for XMRV/MLV sequences. In contrast, 40 selected control subjects were negative. CSF patients and controls were negative for mitochondrial mouse-specific DNA sequences. These findings do not confirm the high frequency of MLV-related viruses infection in CFS patients, but also contrast the widespread laboratory contamination previously suggested.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Base Sequence
-
Case-Control Studies
-
DNA, Mitochondrial / genetics
-
DNA, Viral / genetics
-
Fatigue Syndrome, Chronic / genetics
-
Fatigue Syndrome, Chronic / virology*
-
Genes, Viral*
-
Genes, gag*
-
HIV / genetics
-
HIV / pathogenicity
-
Humans
-
Leukemia Virus, Murine / classification
-
Leukemia Virus, Murine / genetics
-
Mice
-
Retroviridae Infections / diagnosis*
-
Retroviridae Infections / virology
-
Sequence Alignment
-
Xenotropic murine leukemia virus-related virus / classification
-
Xenotropic murine leukemia virus-related virus / genetics
-
Xenotropic murine leukemia virus-related virus / isolation & purification*
Substances
-
DNA, Mitochondrial
-
DNA, Viral