Mycobacterium tuberculosis pneumonia and bacteremia after allogeneic hematopoietic stem cell transplant: report of an instructive pediatric case

Erika Biral; Maura Faraci; Edoardo Lanino; Giuseppe Morreale; Stefano Giardino; Cristina Moroni; Giuseppe Losurdo; Gian Michele Magnano; Evelina Senno; Elio Castagnola

Mycobacterium tuberculosis pneumonia and bacteremia after allogeneic hematopoietic stem cell transplant: report of an instructive pediatric case

New Microbiol. 2012 Jul;35(3):353-7. Epub 2012 Jun 30.

Authors

Erika Biral¹, Maura Faraci, Edoardo Lanino, Giuseppe Morreale, Stefano Giardino, Cristina Moroni, Giuseppe Losurdo, Gian Michele Magnano, Evelina Senno, Elio Castagnola

Affiliation

¹ Hematology-Oncology Department, G. Gaslini Children's Research Institute, Genova, Italy. [email protected]

PMID: 22842607

Abstract

Pulmonary infections often complicate hematopoietic stem cell transplantation (HSCT) outcome. Uncommon aetiologies, like Mycobacterium tuberculosis, should be considered when the clinical conditions do not fully improve with standard antimicrobial therapy and microbiological evaluations are repeatedly negative for bacteria and fungi. We describe an interesting pediatric case of miliary lung tuberculosis after HSCT, which was successfully treated after administering the appropriate therapy.

Publication types

Case Reports

MeSH terms

Antibiotics, Antitubercular / therapeutic use
Bacteremia / microbiology*
Bacteremia / pathology
Child
Hematopoietic Stem Cell Transplantation*
Humans
Male
Mycobacterium tuberculosis / isolation & purification
Mycobacterium tuberculosis / pathogenicity*
Pneumonia, Bacterial / drug therapy
Pneumonia, Bacterial / microbiology*
Pneumonia, Bacterial / pathology
Thorax / diagnostic imaging
Thorax / microbiology
Thorax / pathology
Tomography, X-Ray Computed / methods
Transplantation, Homologous
Treatment Outcome
Tuberculosis / drug therapy
Tuberculosis / microbiology*
Tuberculosis / pathology
Ultrasonography

Substances

Antibiotics, Antitubercular