Abstract
Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A new report sheds light on the function of SIRT7, the least understood member of the Sirtuin family by identifying its locus-specific H3K18 deacetylase activity, and linking it to maintenance of cellular transformation in malignancies.
MeSH terms
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Acetylation
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Animals
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism*
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Cell Transformation, Neoplastic / pathology
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Histones / genetics
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Histones / metabolism
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Humans
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Promoter Regions, Genetic
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Ribosomal Proteins / metabolism
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Sirtuins / metabolism*
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ets-Domain Protein Elk-4 / metabolism
Substances
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ELK4 protein, human
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Histones
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Ribosomal Proteins
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SIRT7 protein, human
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ets-Domain Protein Elk-4
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Sirtuins