Alfred E. Mann's vision is to create organizations that will help medical innovations born in academic environments evolve into commercially fit solutions, without the risk of being abandoned under the financial pressures early stage start-ups often experience. In 1998, Mann worked with Stephen Sample, president of USC, to create the first AMI for Biomedical Engineering, an organization fueled by an endowment valued at approximately US$160 million today. Technology-acceleration centers come in different flavors. AMI USC's recipe has evolved since its creation, with edits that incorporate lessons learned and improvements brought by its expanding network of talented resource people. Its 15-member staff, consisting of three-fourths industry professionals, includes seasoned generalists and specialists in medical technology commercialization. Although the support varies with each invention, some recurring ingredients weave into the AMI approach to accelerating medical innovation.