Thinking outside the synapse: glycine at extrasynaptic NMDA receptors

John A Gray; Roger A Nicoll

doi:10.1016/j.cell.2012.07.013

Thinking outside the synapse: glycine at extrasynaptic NMDA receptors

Cell. 2012 Aug 3;150(3):455-6. doi: 10.1016/j.cell.2012.07.013.

Authors

John A Gray¹, Roger A Nicoll

Affiliation

¹ Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA. [email protected]

PMID: 22863001
DOI: 10.1016/j.cell.2012.07.013

Abstract

In this issue, Papouin et al. show that glycine is the endogenous coagonist for extrasynaptic NMDA receptors (NMDARs), unlike at synapses where the coagonist is d-serine. By enzymatically degrading endogenous glycine, they begin to address the enigmatic physiological and pathological roles for extrasynaptic NMDARs.

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