Abstract
We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Disease Models, Animal*
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Female
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Lung Neoplasms / genetics
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Lung Neoplasms / metabolism*
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Lung Neoplasms / pathology
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Male
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Mice
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Mice, Transgenic
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Neoplasms, Experimental / genetics
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Neoplasms, Experimental / metabolism*
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Neoplasms, Experimental / pathology
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Oncogene Protein p21(ras) / genetics
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Oncogene Protein p21(ras) / metabolism*
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Pancreatic Neoplasms / genetics
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Pancreatic Neoplasms / metabolism
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Pancreatic Neoplasms / pathology
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Signal Transduction* / genetics
Substances
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Oncogene Protein p21(ras)