Abstract
Regioselective ring expansion of alkynyl cyclopropanes to highly substituted cyclobutenes was developed. The reaction involves a copper-catalyzed cycloaddition of an alkyne with an arylsulfonyl azide and a silver-catalyzed carbene formation followed by ring expansion of a cyclopropyl carbene intermediate.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Azides / chemistry
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Catalysis
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Copper / chemistry
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Cycloaddition Reaction
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Cyclopropanes / chemistry*
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Methane / analogs & derivatives
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Methane / chemistry
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Silver / chemistry
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Triazoles / chemistry*
Substances
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Alkynes
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Azides
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Cyclopropanes
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Triazoles
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carbene
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Silver
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Copper
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Methane