Hydrogels incorporating GdDOTA: towards highly efficient dual T1/T2 MRI contrast agents

Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9119-22. doi: 10.1002/anie.201203190. Epub 2012 Aug 2.

Abstract

Do not tumble dry: Gadolinium-DOTA encapsulated into polysaccharide nanoparticles (GdDOTA NPs) exhibited high relaxivity (r(1) =101.7 s(-1) mM(-1) per Gd(3+) ion at 37 °C and 20 MHz). This high relaxation rate is due to efficient Gd loading, reduced tumbling of the Gd complex, and the hydrogel nature of the nanoparticles. The efficacy of the nanoparticles as a T(1)/T(2) dual-mode contrast agent was studied in C6 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Contrast Media / chemistry*
  • Heterocyclic Compounds / chemistry*
  • Hydrogels / chemistry*
  • Magnetic Resonance Imaging
  • Nanoparticles / chemistry
  • Organometallic Compounds / chemistry*
  • Polysaccharides / chemistry
  • Rats

Substances

  • Contrast Media
  • Heterocyclic Compounds
  • Hydrogels
  • Organometallic Compounds
  • Polysaccharides
  • gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate