The N676D and G697R mutations in the kinase domain of FLT3 confer resistance to the inhibitor AC220

MeSH terms

• Amino Acid Substitution
• Benzothiazoles / pharmacology*
• Cell Line, Tumor
• Drug Resistance, Neoplasm / genetics*
• Female
• Humans
• Leukemia, Myeloid, Acute / drug therapy
• Leukemia, Myeloid, Acute / enzymology
• Leukemia, Myeloid, Acute / genetics*
• Male
• Mutation, Missense*
• Phenylurea Compounds / pharmacology*
• Protein Kinase Inhibitors / pharmacology*
• Protein Structure, Tertiary
• fms-Like Tyrosine Kinase 3 / antagonists & inhibitors*
• fms-Like Tyrosine Kinase 3 / genetics*
• fms-Like Tyrosine Kinase 3 / metabolism