Abstract
Objective:
To study the effects of "Attenuation and Synergia" for Bushenhuoxue Granules (BSHXG) on Parkinson's patients.
Methods:
120 patients were enrolled and divided into two groups randomly, the control group were treated with placebo and treatment group with BSHXG, both groups based on Madopar treatment. Double-blinded clinical trial was adopted in treatment period. Follow-up period for 6 months. Usage of Madopar and score of treatment complications were adopted to measure related motor complications before and after treatment.
Results:
Usage of Madopar and score of treatment complications in treatment group were decreased (P < 0.05). No adverse effects were found in this trial.
Conclusion:
BSHXG can decrease the side-effects of Madopar and put off the development of PD. The effects of "Attenuation and Synergia" of BSHXG becomes clear with time.
Publication types
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English Abstract
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Aged
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Aged, 80 and over
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Antiparkinson Agents / pharmacology
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Antiparkinson Agents / therapeutic use*
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Benserazide / administration & dosage
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Benserazide / adverse effects
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Benserazide / therapeutic use*
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Constipation / epidemiology
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Constipation / etiology
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Double-Blind Method
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Drug Combinations
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Drugs, Chinese Herbal / pharmacology
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Drugs, Chinese Herbal / therapeutic use*
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Female
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Humans
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Levodopa / administration & dosage
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Levodopa / adverse effects
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Levodopa / therapeutic use*
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Male
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Middle Aged
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Parkinson Disease / drug therapy*
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Parkinson Disease / physiopathology
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Phytotherapy*
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Plants, Medicinal / chemistry
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Treatment Outcome
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Urination Disorders / epidemiology
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Urination Disorders / etiology
Substances
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Antiparkinson Agents
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Drug Combinations
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Drugs, Chinese Herbal
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benserazide, levodopa drug combination
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bushen huoxue
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Levodopa
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Benserazide