A novel mutation in exon 8 of C1 inhibitor (C1INH) gene leads to abolish its physiological stop codon in a large Chinese family with hereditary angioedema type I

Exp Dermatol. 2012 Oct;21(10):788-91. doi: 10.1111/j.1600-0625.2012.01563.x. Epub 2012 Aug 7.

Abstract

C1 inhibitor (C1INH) plays an important role in the classical pathway of the complement system. Mutations in C1INH gene cause quantitative or qualitative deficiencies in C1INH, which can lead to hereditary angioedema (HAE) type I or II. Here, we identified a novel frame-shift mutation c.1391-1445del55 (p.v464fsx556) in exon 8 in a large Chinese family with HAE type I. This 55 base pairs deletion abolishes the original stop codon and introduces a new stop codon 220 bp downstream of the original one, and leads to mutated C1INH protein prolonged from 500 to 556 amino acids. The levels of C4 and C1INH as well as C1INH activity in serum were significantly reduced in affected individuals. This is the first report of a novel mutation abolishing the physiological stop codon of C1INH gene in a large Chinese family with HAE type I.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Asian People / genetics
  • Base Sequence
  • China
  • Codon, Terminator / genetics
  • Complement C1 Inactivator Proteins / genetics*
  • Complement C1 Inhibitor Protein
  • DNA Mutational Analysis
  • Exons
  • Female
  • Frameshift Mutation*
  • Hereditary Angioedema Types I and II / genetics*
  • Hereditary Angioedema Types I and II / immunology
  • Humans
  • Male
  • Middle Aged
  • Pedigree

Substances

  • Codon, Terminator
  • Complement C1 Inactivator Proteins
  • Complement C1 Inhibitor Protein
  • SERPING1 protein, human