Redox self-sufficient biocatalyst network for the amination of primary alcohols

Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9156-9. doi: 10.1002/anie.201204683. Epub 2012 Aug 9.

Abstract

Driving the machinery: A biocatalytic redox-neutral cascade for the preparation of terminal primary amines from primary alcohols at the expense of ammonia has been established in a one-pot one-step method. Applying this artificial biocatalyst network, long-chain 1,ω-alkanediols were converted into diamines, which are building blocks for polymers, in up to 99 % conversion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Dehydrogenase / metabolism
  • Alcohols / chemistry
  • Alcohols / metabolism*
  • Amination
  • Amines / chemistry
  • Amines / metabolism
  • Biocatalysis
  • NAD / chemistry
  • Oxidation-Reduction
  • Polymers / chemistry
  • Transaminases / metabolism

Substances

  • Alcohols
  • Amines
  • Polymers
  • NAD
  • Alcohol Dehydrogenase
  • Transaminases