Abstract
The rates of oxidation of fatty acids by CYP119 compound I were dependent on the pH of the medium. The plot shows log k values for reactions of acids as a function of pH, where the slopes indicate mixed third-order and fourth-order dependence on base concentration. For palmitic acid, the rate increased 50-fold over the pH range 6.8-7.3.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Archaeal Proteins / chemistry
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Archaeal Proteins / metabolism*
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Caprylates / chemistry
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Caprylates / metabolism
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Cytochrome P-450 Enzyme System / chemistry
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Cytochrome P-450 Enzyme System / metabolism*
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Fatty Acids / chemistry
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Fatty Acids / metabolism*
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Hydrogen-Ion Concentration
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Kinetics
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Lauric Acids / chemistry
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Lauric Acids / metabolism
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Oxidation-Reduction
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Palmitic Acid / chemistry
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Palmitic Acid / metabolism
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Stereoisomerism
Substances
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Archaeal Proteins
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Caprylates
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Fatty Acids
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Lauric Acids
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lauric acid
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Palmitic Acid
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Cytochrome P-450 Enzyme System
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CYP119 protein, Sulfolobus solfataricus
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octanoic acid