Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5989-94. doi: 10.1016/j.bmcl.2012.07.005. Epub 2012 Jul 20.

Abstract

Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.

MeSH terms

  • Animals
  • Binding Sites / drug effects
  • Blood Proteins / chemistry
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Gram-Negative Bacteria / drug effects*
  • Gram-Negative Bacterial Infections / drug therapy*
  • Gram-Negative Bacterial Infections / microbiology
  • Humans
  • Mice
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Structure
  • Monobactams / chemical synthesis
  • Monobactams / chemistry
  • Monobactams / pharmacology*
  • Rats
  • Structure-Activity Relationship

Substances

  • Blood Proteins
  • Monobactams