Leishmanicidal and anticandidal activity of constituents of Indian edible mushroom Astraeus hygrometricus

Chem Biodivers. 2012 Aug;9(8):1517-24. doi: 10.1002/cbdv.201100272.

Abstract

Two new lanostane-type triterpenes, 1 and 2, were isolated from Astraeus hygrometricus. The structures were established by IR, (1)H- and (13)C-NMR, MS, and X-ray crystallographic experiments. The triterpenes exhibited excellent in vitro toxicities against Candida albicans, comparable to standard antifungal antibiotics. The triterpene 2 significantly inhibited the growth of Leishmania donovani promastigotes in vitro. The triterpene skeleton may be considered a template structure in search for new compounds with anticandidal and leishmanicidal activity.

MeSH terms

  • Animals
  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Antiprotozoal Agents / chemistry*
  • Antiprotozoal Agents / isolation & purification
  • Antiprotozoal Agents / pharmacology*
  • Basidiomycota / chemistry*
  • Candida albicans / drug effects
  • Candidiasis / drug therapy
  • Crystallography, X-Ray
  • Humans
  • Leishmania donovani / drug effects
  • Leishmaniasis, Visceral / drug therapy
  • Mice
  • Mice, Inbred BALB C
  • Models, Molecular
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Antifungal Agents
  • Antiprotozoal Agents
  • Triterpenes