Abstract
Weaned pigs from a line bred for increased feed efficiency were enrolled in a study of the role of host genes in the response to infection with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Four of the pigs were euthanatized early in the study due to weight loss with illness and poor body condition; 2 pigs before PRRSV infection and the other 2 pigs approximately 2 weeks after virus inoculation. The 2 inoculated pigs failed to produce PRRSV-specific antibodies. Gross findings included pneumonia, absence of a detectable thymus, and small secondary lymphoid tissues. Histologically, lymph nodes, spleen, tonsils, and Peyer's patches were sparsely cellular with decreased to absent T and B lymphocytes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis
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Antibodies, Viral / immunology
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B-Lymphocytes / immunology
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B-Lymphocytes / virology
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Diagnosis, Differential
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Immunologic Deficiency Syndromes / pathology
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Immunologic Deficiency Syndromes / veterinary*
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Immunologic Deficiency Syndromes / virology
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Lung / pathology
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Lung / virology
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Lymph Nodes / immunology
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Lymph Nodes / pathology
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Lymph Nodes / virology
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Lymphoid Tissue / immunology
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Lymphoid Tissue / pathology*
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Lymphoid Tissue / virology
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Male
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Palatine Tonsil / immunology
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Palatine Tonsil / pathology
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Palatine Tonsil / virology
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Peyer's Patches / immunology
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Peyer's Patches / pathology
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Peyer's Patches / virology
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Pneumonia / veterinary
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Pneumonia / virology
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Porcine Reproductive and Respiratory Syndrome / immunology*
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Porcine Reproductive and Respiratory Syndrome / pathology
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Porcine Reproductive and Respiratory Syndrome / virology
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Porcine respiratory and reproductive syndrome virus / genetics
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Porcine respiratory and reproductive syndrome virus / immunology
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Porcine respiratory and reproductive syndrome virus / isolation & purification*
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Spleen / immunology
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Spleen / pathology
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Spleen / virology
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Swine
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T-Lymphocytes / immunology
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T-Lymphocytes / virology
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Viremia / veterinary