Cells undergo continuous and simultaneous external influences regulating their behavior. As an example, during differentiation, they go through different stages of maturation and gene expression is regulated by several simultaneous signaling pathways. We often tend at separating the nuclear pathways from the signaling ones initiated at membrane receptors. However, it is essential to keep in mind that all these pathways are interconnected to achieve a fine regulation of cell functions. The regulation of transcription by nuclear receptors has been thoroughly studied, but it now appears that a critical level of this regulation involves the action of several kinases that target the nuclear receptors themselves as well as their partners. The purpose of this review is to highlight the importance of one family of the mitogen-activated protein kinase (MAPK) superfamily, the MEK/ERK1/2 pathway, in the transcriptional activity of nuclear receptors.
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