Abstract
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family that also comprises VEGF-A (VEGF), VEGF-B, VEGF-C, and VEGF-D. Unlike VEGF, PlGF is dispensable for development and health but has diverse nonredundant roles in tissue ischemia, malignancy, inflammation, and multiple other diseases. Genetic and pharmacological gain-of-function and loss-of-function studies have identified molecular mechanisms of this multitasking cytokine and characterized the therapeutic potential of delivering or blocking PlGF for various disorders.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arthritis, Rheumatoid / drug therapy
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Cardiovascular Diseases / drug therapy
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Cardiovascular Diseases / etiology
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Colitis / etiology
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Cytokines / antagonists & inhibitors
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Cytokines / deficiency
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Cytokines / genetics
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Cytokines / physiology*
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Growth and Development / physiology
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Hematologic Diseases / drug therapy
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Hematologic Diseases / etiology
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Humans
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Hypersensitivity, Delayed / drug therapy
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Liver Cirrhosis / drug therapy
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Mice
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Neoplasms / drug therapy
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Neoplasms / etiology
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Obesity / drug therapy
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Placenta Growth Factor
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Pregnancy Proteins / antagonists & inhibitors
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Pregnancy Proteins / deficiency
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Pregnancy Proteins / genetics
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Pregnancy Proteins / physiology*
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Pulmonary Emphysema / drug therapy
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Sepsis / etiology
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Signal Transduction / physiology
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Vascular Endothelial Growth Factor Receptor-1 / physiology
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Wound Healing / physiology
Substances
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Cytokines
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PGF protein, human
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Pgf protein, mouse
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Pregnancy Proteins
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Placenta Growth Factor
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FLT1 protein, human
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Vascular Endothelial Growth Factor Receptor-1