Abstract
Although the c-Myc oncogene is frequently deregulated in human cancer, its involvement in the pathogenesis of glioblastoma is not clear. We conducted immunohistochemical analysis of the expression of c-Myc, polycomb ring finger oncogene (BMI1), and acetylation of the lysine 9 (H3K9Ac) of histone 3 in 48 patients with glioblastoma who underwent surgery followed by radiotherapy and temozolomide treatment. The expression of c-Myc, BMI1, and H3K9ac was correlated with clinical characteristics and outcome. We found that overexpression of c-Myc was significantly associated with that of BMI1 (P = .009), and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival (P < .0001 and P = .0009, respectively). Our results provide the first evidence of the prognostic value of c-Myc and associated genes in patients with glioblastoma. The favorable effect of c-Myc and BMI1 expression on survival is likely mediated by the sensitization of cancer cells to radiotherapy and temozolomide through the activation of apoptotic pathways.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antineoplastic Agents, Alkylating / therapeutic use
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Brain Neoplasms / drug therapy
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Brain Neoplasms / metabolism*
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Brain Neoplasms / mortality
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Brain Neoplasms / radiotherapy
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Combined Modality Therapy
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Dacarbazine / analogs & derivatives
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Dacarbazine / therapeutic use
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Female
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Glioblastoma / drug therapy
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Glioblastoma / metabolism*
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Glioblastoma / mortality
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Glioblastoma / radiotherapy
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Humans
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Male
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Middle Aged
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism*
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Polycomb Repressive Complex 1
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Prognosis
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism*
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Proto-Oncogene Proteins c-myc / genetics
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Proto-Oncogene Proteins c-myc / metabolism*
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Repressor Proteins / genetics
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Repressor Proteins / metabolism*
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Survival Rate
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Temozolomide
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Treatment Outcome
Substances
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Antineoplastic Agents, Alkylating
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BMI1 protein, human
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MYC protein, human
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Nuclear Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-myc
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Repressor Proteins
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Dacarbazine
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Polycomb Repressive Complex 1
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Temozolomide