Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function

Cell Cycle. 2012 Sep 15;11(18):3351-2. doi: 10.4161/cc.21876. Epub 2012 Aug 23.

Abstract

Comment on: Beier UH, et al. Sci Signal 2012; 5:ra45.

Publication types

  • Editorial

MeSH terms

  • Acetylation / drug effects
  • Animals
  • Forkhead Transcription Factors / metabolism*
  • Gene Deletion
  • Graft Rejection / immunology
  • Histone Deacetylase Inhibitors / pharmacology*
  • Histone Deacetylases / metabolism*
  • Humans
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / metabolism
  • Models, Immunological
  • Sirtuin 1 / metabolism
  • T-Lymphocytes, Regulatory / drug effects
  • T-Lymphocytes, Regulatory / enzymology*
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Forkhead Transcription Factors
  • Histone Deacetylase Inhibitors
  • Isoenzymes
  • Sirtuin 1
  • Histone Deacetylases