Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease

Christian Landles; Andreas Weiss; Sophie Franklin; David Howland; Gill Bates

doi:10.1371/4fd085bfc9973

Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease

PLoS Curr. 2012 Jul 16:4:e4fd085bfc9973. doi: 10.1371/4fd085bfc9973.

Authors

Christian Landles, Andreas Weiss, Sophie Franklin, David Howland, Gill Bates

No abstract available

Grants and funding

This work was funded by the CHDI Foundation, a privately funded non-profit biomedical research organisation exclusively dedicated to discovering and developing therapeutics that slow the progression of HD. For this study CHDI Foundation assisted with the generation of Casp6-deficient mice.