Abstract
Quinones are plant-derived secondary metabolites that present some anti-proliferation and anti-metastasis effects in various cancer types both in vitro and in vivo. This review focuses on the anti-cancer prospects of plant-derived quinones, namely, aloe-emodin, juglone, β-lapachol, plumbagin, shikonin, and thymoquinone. We intend to summarize their anti-cancer effects and investigate the mechanism of actions to promote the research and development of anti-cancer agents from quinones.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzoquinones / isolation & purification
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Benzoquinones / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Naphthoquinones / isolation & purification
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Naphthoquinones / pharmacology
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Neoplasms / drug therapy
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Plant Extracts / chemistry*
Substances
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Anthraquinones
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Antineoplastic Agents, Phytogenic
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Benzoquinones
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Naphthoquinones
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Plant Extracts
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shikonin
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lapachol
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aloe emodin
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thymoquinone
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juglone
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plumbagin