Multiple synchronous outbreaks of Puumala virus, Germany, 2010

Jakob Ettinger; Jorg Hofmann; Martin Enders; Friedemann Tewald; Rainer M Oehme; Ulrike M Rosenfeld; Hanan Sheikh Ali; Mathias Schlegel; Sandra Essbauer; Anja Osterberg; Jens Jacob; Daniela Reil; Boris Klempa; Rainer G Ulrich; Detlev H Kruger

doi:10.3201/eid1809.111447

Multiple synchronous outbreaks of Puumala virus, Germany, 2010

Emerg Infect Dis. 2012 Sep;18(9):1461-4. doi: 10.3201/eid1809.111447.

Authors

Jakob Ettinger¹, Jorg Hofmann, Martin Enders, Friedemann Tewald, Rainer M Oehme, Ulrike M Rosenfeld, Hanan Sheikh Ali, Mathias Schlegel, Sandra Essbauer, Anja Osterberg, Jens Jacob, Daniela Reil, Boris Klempa, Rainer G Ulrich, Detlev H Kruger

Affiliation

¹ Charité Medical School and Labor Berlin Charité-Vivantes GmbH, Berlin, Germany.

Abstract

To investigate 2,017 cases of hantavirus disease in Germany, we compared 38 new patient-derived Puumala virus RNA sequences identified in 2010 with bank vole-derived small segment RNA sequences. The epidemic process was driven by outbreaks of 6 Puumala virus clades comprising strains of human and vole origin. Each clade corresponded to a different outbreak region.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Disease Outbreaks*
Germany / epidemiology
Hemorrhagic Fever with Renal Syndrome / epidemiology*
Humans
Phylogeny
Puumala virus / classification
Puumala virus / genetics*
RNA, Viral

Substances

RNA, Viral