Abstract
In Belgium, decreasing macrolide, lincosamide, streptogramins B, and tetracycline use during 1997-2007 correlated significantly with decreasing macrolide-resistant Streptococcus pyogenes during 1999-2009. Maintaining drug use below a critical threshold corresponded with low-level macrolide-resistant S. pyogenes and an increased number of erm(A)-harboring emm77 S. pyogenes with low fitness costs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Proteins / genetics
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Belgium
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Drug Resistance, Bacterial / genetics
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Humans
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Macrolides / pharmacology*
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Macrolides / therapeutic use*
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Membrane Proteins / genetics
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Methyltransferases / genetics
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Microbial Sensitivity Tests
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Streptococcal Infections / drug therapy*
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Streptococcus pyogenes / drug effects*
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Streptococcus pyogenes / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Macrolides
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MefA protein, Streptococcus
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Membrane Proteins
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Methyltransferases
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ErmA protein, Bacteria