Genetic heterogeneity and recombination in human type 2 astroviruses

J Clin Microbiol. 2012 Nov;50(11):3760-4. doi: 10.1128/JCM.02102-12. Epub 2012 Aug 29.

Abstract

Novel lineages of human astrovirus (HAstV) types 2, 2c, and 2d have been identified. Upon sequencing of the 3' end of the genome, the type 2c and 2d HAstVs were found to be open reading frame 1b (ORF1b)-ORF2 recombinant, with ORF1b being derived from type 3 and type 1 HAstVs, respectively. An ORF2 interlineage recombinant strain, 2c/2b, was also identified.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cluster Analysis
  • Genetic Heterogeneity*
  • Humans
  • Mamastrovirus / classification*
  • Mamastrovirus / genetics*
  • Molecular Sequence Data
  • Open Reading Frames
  • Phylogeny
  • RNA, Viral / genetics
  • Recombination, Genetic*
  • Sequence Analysis, DNA

Substances

  • RNA, Viral

Associated data

  • GENBANK/JX087963
  • GENBANK/JX087964