A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold

Gwenn E Mulder; John A W Kruijtzer; Rob M J Liskamp

doi:10.1039/c2cc35310e

A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold

Chem Commun (Camb). 2012 Oct 14;48(80):10007-9. doi: 10.1039/c2cc35310e.

Authors

Gwenn E Mulder¹, John A W Kruijtzer, Rob M J Liskamp

Affiliation

¹ Medicinal Chemistry & Chemical Biology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, NL-3508 TB Utrecht, The Netherlands.

PMID: 22935751
DOI: 10.1039/c2cc35310e

Abstract

We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in HIV-gp120, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.

MeSH terms

Amino Acid Sequence
Epitopes / chemistry*
HIV / chemistry*
HIV Envelope Protein gp120 / chemistry*
Models, Molecular
Peptides, Cyclic / chemical synthesis*
Peptides, Cyclic / chemistry
Small Molecule Libraries / chemical synthesis*
Small Molecule Libraries / chemistry

Substances

Epitopes
HIV Envelope Protein gp120
Peptides, Cyclic
Small Molecule Libraries