The effect of low-magnitude, high-frequency vibration stimuli on the bone healing of rat incisor extraction socket

J Biomech Eng. 2012 Sep;134(9):091001. doi: 10.1115/1.4007247.

Abstract

Effects of small vibration stimuli on bone formation have been reported. In the present study, we used morphological and morphometric procedures to elucidate whether low-magnitude, high-frequency (LMHF) vibration stimuli could enhance the bone healing of rat incisor extraction sockets. After extraction of incisors from six-week-old rats, animals were assigned into a control group and two experimental groups to receive 50 Hz stimuli at either 0.05 mm or 0.2 mm peak-to-peak for an hour/day. LMHF vibration stimuli were generated by placing the mandibles of the animals onto a vibration generator. All groups were subdivided into two, according to the study periods (1 and 3 weeks). After the study period, undecalcified ground sections were taken and morphological and morphometric analyses performed. At both 1 and 3 weeks, newly formed bone was observed mainly in the upper wall of the extraction socket in all groups. Morphometric analyses revealed that the trabecular thickness in both experimental groups at 1 week was significantly greater than that in the control. LMHF vibration stimuli had a positive effect on bone at the early stage of bone healing, particularly in trabecular thickness, at the incisor extraction socket.

MeSH terms

  • Animals
  • Bone and Bones / pathology
  • Bone and Bones / physiology*
  • Incisor*
  • Male
  • Osteogenesis*
  • Rats
  • Rats, Wistar
  • Tooth Extraction*
  • Vibration / therapeutic use*
  • Wound Healing*