Abstract
This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / enzymology
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Enzyme Inhibitors* / isolation & purification
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Enzyme Inhibitors* / pharmacology
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Enzyme Inhibitors* / therapeutic use
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Humans
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Molecular Structure
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Obesity / drug therapy
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Obesity / enzymology
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Plant Preparations* / isolation & purification
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Plant Preparations* / pharmacology
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Plant Preparations* / therapeutic use
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Plants, Medicinal / chemistry*
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Plant Preparations
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PTPN1 protein, human
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Protein Tyrosine Phosphatase, Non-Receptor Type 1