Abstract
This study was designed to investigate whether polymerized human placenta hemoglobin (PolyPHb) attenuated hemorrhagic shock-induced lung injury. A mean arterial pressure (MAP) of 30mmHg was maintained for 60 min. Then, all the rats were randomly resuscitated with hetastarch, whole blood, or PolyPHb. The result indicated that PolyPHb greatly improved the MAP and pulmonary function, and significantly reduced the release of inflammatory cytokines, histopathological changes, and pulmonary edema. Therefore, our findings suggest that PolyPHb could reduce pulmonary injury after hemorrhagic shock, and this effect was probably associated with the depressed inflammatory response.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arterial Pressure / drug effects
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Cytokines / metabolism
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Female
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Hemoglobins / administration & dosage*
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Hemoglobins / chemical synthesis
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Hemoglobins / metabolism
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Humans
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Inflammation Mediators / metabolism
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Lung / drug effects*
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Lung / immunology
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Lung / pathology
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Lung Injury / etiology
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Lung Injury / immunology
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Lung Injury / prevention & control*
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Male
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Placenta / metabolism
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Polymerization
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Pregnancy
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Pulmonary Edema / etiology
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Pulmonary Edema / immunology
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Pulmonary Edema / prevention & control*
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Rats
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Rats, Sprague-Dawley
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Respiratory Function Tests
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Resuscitation*
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Shock, Hemorrhagic / complications
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Shock, Hemorrhagic / drug therapy*
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Shock, Hemorrhagic / immunology
Substances
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Cytokines
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Hemoglobins
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Inflammation Mediators