Abstract
Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors.
Keywords:
Caesalpinia sappan; inhibition; melanogenesis; sappanone A; tyrosinase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Caesalpinia / chemistry*
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Cell Proliferation / drug effects
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Enzyme Inhibitors / pharmacology*
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Isoflavones / pharmacology*
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Melanins / biosynthesis*
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Melanoma, Experimental / drug therapy
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Melanoma, Experimental / pathology*
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Mice
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Monophenol Monooxygenase / antagonists & inhibitors
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Monophenol Monooxygenase / genetics
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Monophenol Monooxygenase / metabolism
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Plant Extracts / pharmacology*
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RNA, Messenger / genetics
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Real-Time Polymerase Chain Reaction
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Enzyme Inhibitors
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Isoflavones
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Melanins
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Plant Extracts
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RNA, Messenger
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sappanone A
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Monophenol Monooxygenase