Objectives: To study the relationship between serum total testosterone (TT) and 24-hour urinary sodium excretion in newly diagnosed stage 1 essential hypertensive patients with normal renal function.
Study design: In total, 80 never-treated stage 1 hypertensive patients were included. All patients provided medical history and underwent physical examination, blood pressure measurement, 12-lead electrocardiography, routine urine analysis, biochemical analysis, 24-hour urine collection to measure urinary sodium and protein excretion, and creatinine clearance calculation.
Results: Pearson correlation analysis revealed that logarithmically converted 24-hour urinary sodium excretion was correlated with age (r=-0.399, p<0.0001), body mass index, (r=0.304, p=0.006), systolic blood pressure (r=0.394, p<0.0001), serum potassium (r=0.233, p=0.037), creatinine clearance (r=0.600, p<0.0001), and logarithmically converted serum TT (r=-0.272, p=0.015). Stepwise linear regression analysis revealed that age (p<0.0001), creatinine clearance (p=0.015), systolic blood pressure (p<0.0001), potassium (p=0.021), and serum TT (p=0.002) were independently related to logarithmically converted 24-hour sodium excretion.
Conclusion: We demonstrated that serum TT levels were independently related to 24-hour urinary sodium amount.