In vivo fluorescence imaging with Ag2S quantum dots in the second near-infrared region

Angew Chem Int Ed Engl. 2012 Sep 24;51(39):9818-21. doi: 10.1002/anie.201206059. Epub 2012 Sep 5.

Abstract

Hits the dot: Ag(2)S quantum dots (QDs) with bright near-infrared-II fluorescence emission (around 1200 nm) and six-arm branched PEG surface coating were synthesized for in vivo small-animal imaging. The 6PEG-Ag(2)S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half-life of approximately 4 h. Clearance of the injected 6PEG-Ag(2)S QDs occurs mainly through the biliary pathway in mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Fluorescent Dyes* / chemistry
  • Mice
  • Mice, Inbred BALB C
  • Neoplasms / diagnosis*
  • Optical Imaging / methods*
  • Quantum Dots*
  • Silver Compounds* / chemistry
  • Spectroscopy, Near-Infrared / methods

Substances

  • Fluorescent Dyes
  • Silver Compounds
  • silver sulfide