SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions

J Biol Chem. 2012 Sep 7;287(37):30897-905. doi: 10.1074/jbc.R111.309302. Epub 2012 Sep 5.

Abstract

Chromatin-remodeling enzymes play essential roles in many biological processes, including gene expression, DNA replication and repair, and cell division. Although one such complex, SWI/SNF, has been extensively studied, new discoveries are still being made. Here, we review SWI/SNF biochemistry; highlight recent genomic and proteomic advances; and address the role of SWI/SNF in human diseases, including cancer and viral infections. These studies have greatly increased our understanding of complex nuclear processes.

Publication types

  • Review

MeSH terms

  • Chromosomal Proteins, Non-Histone / genetics
  • Chromosomal Proteins, Non-Histone / metabolism*
  • DNA Repair*
  • DNA Replication*
  • Gene Expression Regulation*
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Virus Diseases / genetics
  • Virus Diseases / metabolism*

Substances

  • Chromosomal Proteins, Non-Histone
  • SWI-SNF-B chromatin-remodeling complex
  • Transcription Factors