Right hepatectomy with extra-hepatic vascular division prior to transection: intention-to-treat analysis of a standardized policy

HPB (Oxford). 2012 Oct;14(10):688-99. doi: 10.1111/j.1477-2574.2012.00519.x. Epub 2012 Jul 4.

Abstract

Background: Right hepatectomy (RH) is the most common type of major hepatectomy and can be achieved without portal triad clamping (PTC) in non-cirrhotic liver. The present study reviews our standardized policy of performing RH without systematic PTC.

Methods: One hundred and eighty-one consecutive RH were performed in non-cirrhotic patients, with division of the right afferent and efferent blood vessels prior to transection, without systematically using PTC. Prospectively collected data were analysed, focusing on the following endpoints: need for salvage PTC, ischaemic time, blood loss and post-operative outcome.

Results: Extra-hepatic division of the right hepatic vessels was feasible in all patients, but was ineffective in 48 patients (26.5%) who required salvage PTC during transection. In those patients, the median ischaemic time was 20 min. The median blood loss was 500 ml (50-3000). Six patients (3.3%) experienced post-operative liver failure. Overall morbidity, severe morbidity and mortality were 42%, 12.1% and 1.6%, respectively, with peri-operative transfusion rate (16.6%) being the only factor associated with morbidity.

Discussion: By performing RH with extra-hepatic vascular division prior to transection, PTC can be safely avoided in the majority of patients.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Loss, Surgical / prevention & control
  • Blood Transfusion
  • Chi-Square Distribution
  • Feasibility Studies
  • Female
  • Hepatectomy / adverse effects
  • Hepatectomy / methods*
  • Hepatectomy / mortality
  • Hepatectomy / standards
  • Hepatic Artery / surgery
  • Hepatic Veins / surgery
  • Humans
  • Intention to Treat Analysis
  • Liver / blood supply*
  • Liver / surgery*
  • Liver Failure / etiology
  • Liver Failure / mortality
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Portal Vein / surgery
  • Quality of Health Care / standards
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Vascular Surgical Procedures / adverse effects
  • Vascular Surgical Procedures / methods*
  • Vascular Surgical Procedures / mortality
  • Vascular Surgical Procedures / standards
  • Young Adult