A case of NDM-1-producing Acinetobacter baumannii transferred from India to Japan

J Infect Chemother. 2013 Apr;19(2):330-2. doi: 10.1007/s10156-012-0469-5. Epub 2012 Sep 12.

Abstract

A 52-year-old male Japanese businessman with massive cerebral bleeding was transferred from India to Japan and was admitted to our hospital. Multidrug-resistant Acinetobacter baumannii was isolated from his sputum. The minimum inhibitory concentrations for this strain were as follows: imipenem, 64 μg/ml; meropenem, 32 μg/ml; ciprofloxacin, 16 μg/ml; amikacin, 16 μg/ml; aztreonam, 16 μg/ml; colistin, <1 μg/ml. This A. baumannii strain had both bla NDM-1 and bla OXA-23 by polymerase chain reaction analysis. In Japan, NDM-1-producing bacteria are extremely rare in clinical specimens. To date, three NDM-1-positive cases have been detected in Japan, and this is the first case of A. baumannii-producing NDM-1 in Japan. Our case suggests that NDM-1-producing bacteria could be introduced into our country easily. There is concern that various resistant bacteria may be transferred from epidemic countries as a result of international medical care.

Publication types

  • Case Reports

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / enzymology*
  • Acinetobacter baumannii / genetics
  • Acinetobacter baumannii / isolation & purification*
  • Anti-Bacterial Agents
  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / genetics
  • Humans
  • India
  • Japan
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Typing
  • Polymerase Chain Reaction
  • Public Health Surveillance
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • beta-Lactamases
  • beta-lactamase NDM-1