Abstract
This issue of Cancer Discovery features an article that describes the use of whole-genome sequencing to discover an actionable genetic alteration that was not detected using a lower resolution diagnostic approach. This finding highlights the growing debate surrounding the optimal deployment of powerful new genomics technologies in the clinical oncology arena.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Humans
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MAP Kinase Kinase Kinases / antagonists & inhibitors*
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Male
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Melanoma / drug therapy*
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Mutation*
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Protein Kinase Inhibitors / therapeutic use*
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Proto-Oncogene Proteins B-raf / genetics*
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Pyridones / therapeutic use*
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Pyrimidinones / therapeutic use*
Substances
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Protein Kinase Inhibitors
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Pyridones
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Pyrimidinones
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TAK 733
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BRAF protein, human
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Proto-Oncogene Proteins B-raf
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MAP Kinase Kinase Kinases