Abstract
An extremely drug-resistant Klebsiella pneumoniae isolate, sequence type ST101, was isolated from a patient in Italy. We describe antibiotic treatment, measures to clear and contain the infection, and a complete sequence analysis of a novel large plasmid, pKPN101-IT, harboring the bla(KPC-2) gene and arising from the threatening recombination of different worldwide-distributed backbones.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / pharmacology
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Drug Resistance, Multiple, Bacterial*
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Humans
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Infection Control / methods*
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Italy
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Klebsiella Infections / drug therapy*
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Klebsiella Infections / microbiology*
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / isolation & purification
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Male
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Middle Aged
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Molecular Sequence Data
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Plasmids
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Sequence Analysis, DNA
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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beta-Lactamases
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beta-lactamase KPC-2, Klebsiella pneumoniae