Four new coumarinolignoids from seeds of Solanum indicum

Hai-Long Yin; Jie-Hui Li; Jian Li; Bin Li; Li Chen; Yin Tian; Shi-Jun Liu; Tao Zhang; Jun-Xing Dong

doi:10.1016/j.fitote.2012.09.002

Four new coumarinolignoids from seeds of Solanum indicum

Fitoterapia. 2013 Jan:84:360-5. doi: 10.1016/j.fitote.2012.09.002. Epub 2012 Sep 11.

Authors

Hai-Long Yin¹, Jie-Hui Li, Jian Li, Bin Li, Li Chen, Yin Tian, Shi-Jun Liu, Tao Zhang, Jun-Xing Dong

Affiliation

¹ Beijing University of Technology, Beijing 100124, China.

PMID: 22975162
DOI: 10.1016/j.fitote.2012.09.002

Abstract

Activity-guided fractionation of seeds of Solanum indicum for anti-HBV activity led to the isolation of two novel coumarinolignoid alkaloids (indicumines A-B, 1-2) and two new coumarinolignoids (indicumines C-D, 3-4), together with four known coumarins (5-8). Their structures were established on the basis of spectroscopic data. The two novel coumarinolignoid alkaloids shows anti-HBV activities through specifically inhibiting the secretion of HBsAg in HepG2.2.15.

MeSH terms

Animals
Coumarins / chemistry*
Molecular Structure
Seeds / chemistry*
Solanum / chemistry*

Substances

Coumarins