Abstract
A 68-year-old woman showed rapidly progressive glomerulonephritis based on the fact that she had 1+ proteinuria (1.1 g/day), a 3+ occult blood reaction, blood urea nitrogen of 32.4 mg/dL, serum creatinine of 2.96 mg/dL, and myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibodies (ANCA) at 52 ELISA Unit (normal range: below 10). A renal biopsy demonstrated a bubbling appearance associated with cellular crescent formation with segmental necrosis. Immunofluorescence studies showed granular IgG3λ deposition along the basement membrane and in the mesangial area. This is the first English-language case report describing MPO-ANCA positive crescentic glomerulonephritis in a patient demonstrating monoclonal immunoglobulin deposition disease with mainly membranous features.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aged
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Antibodies, Antineutrophil Cytoplasmic / metabolism*
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Basement Membrane / immunology
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Basement Membrane / pathology*
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Biopsy
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Disease Progression
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Female
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Fluorescent Antibody Technique
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Glomerular Mesangium / immunology
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Glomerular Mesangium / pathology
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Glomerulonephritis / drug therapy
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Glomerulonephritis / etiology*
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Glomerulonephritis / immunology*
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Glucocorticoids / therapeutic use
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Humans
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Immune System Diseases / complications*
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Immune System Diseases / drug therapy
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Immune System Diseases / immunology*
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Immunoglobulin G / metabolism*
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Peroxidase / immunology*
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Prednisolone / therapeutic use
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Treatment Outcome
Substances
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Antibodies, Antineutrophil Cytoplasmic
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Glucocorticoids
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Immunoglobulin G
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Prednisolone
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Peroxidase