Loss of CD44 attenuates aberrant GM-CSF signaling in Kras G12D hematopoietic progenitor/precursor cells and prolongs the survival of diseased animals

Leukemia. 2013 Mar;27(3):754-7. doi: 10.1038/leu.2012.251. Epub 2012 Aug 31.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Bone Marrow Transplantation
  • Granulocyte-Macrophage Colony-Stimulating Factor / metabolism*
  • Hematopoietic Stem Cells / metabolism
  • Hematopoietic Stem Cells / pathology*
  • Hyaluronan Receptors / physiology*
  • Integrases / metabolism
  • Mice
  • Mice, Knockout
  • Mutation / genetics*
  • Myeloproliferative Disorders / genetics
  • Myeloproliferative Disorders / metabolism
  • Myeloproliferative Disorders / mortality*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / mortality*
  • Proto-Oncogene Proteins p21(ras) / physiology*
  • Signal Transduction
  • Survival Rate

Substances

  • Cd44 protein, mouse
  • Hyaluronan Receptors
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Cre recombinase
  • Integrases
  • Hras protein, mouse
  • Proto-Oncogene Proteins p21(ras)