Abstract
Purpose:
Because of the lack of data on hormone levels in the hormone-free interval of the contraceptive regimens with desogestrel and ethynil estradiol, the objective of this study was to compare hormonal levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, and inhibin B using two contraceptive regimens with those steroids.
Methods:
Prospective and randomized study with 21 patients. Eleven patients received a 21/7 regimen (group 1) and ten patients received a 21/2 placebo/5 ethinyl estradiol 10 μg regimen (group 2).
Results:
We found a significant increase in FSH and LH levels in both groups. There was a significant reduction of inhibin B in the 21/2/5 regimen. No difference in estradiol levels was found.
Conclusions:
Steroids withdrawal in the hormone-free interval causes reduced inhibition of the HPO axis. The significant decrease in inhibin B levels of group 2 suggests better suppression of the HPO axis in the 21/2/5 regimen.
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Biomarkers / blood
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Contraceptives, Oral, Combined / administration & dosage
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Contraceptives, Oral, Combined / pharmacology*
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Contraceptives, Oral, Hormonal / administration & dosage
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Contraceptives, Oral, Hormonal / pharmacology*
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Desogestrel / administration & dosage
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Desogestrel / pharmacology*
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Drug Administration Schedule
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Estradiol / blood
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Ethinyl Estradiol / administration & dosage
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Ethinyl Estradiol / pharmacology*
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Female
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Follicle Stimulating Hormone / blood
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Humans
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Hypothalamo-Hypophyseal System / drug effects*
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Hypothalamo-Hypophyseal System / metabolism
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Inhibins / blood
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Luteinizing Hormone / blood
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Ovary / drug effects*
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Ovary / metabolism
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Prospective Studies
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Young Adult
Substances
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Biomarkers
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Contraceptives, Oral, Combined
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Contraceptives, Oral, Hormonal
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inhibin B
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Ethinyl Estradiol
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Estradiol
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Inhibins
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Desogestrel
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Luteinizing Hormone
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Follicle Stimulating Hormone