Evidence-based practice: reflux in sinusitis

Otolaryngol Clin North Am. 2012 Oct;45(5):983-92. doi: 10.1016/j.otc.2012.06.004. Epub 2012 Aug 9.

Abstract

It is now widely recognized that extraesophageal reflux (reflux reaching structures above the upper esophageal sphincter) has a wide range of effects on the upper aerodigestive tract, as well as the lungs. The degree to which this reflux contributes to the pathophysiology of sinusitis and other sinonasal diseases is still not completely clear, but an increasing body of literature supports a potential role.

Publication types

  • Review

MeSH terms

  • Adult
  • Anti-Ulcer Agents / therapeutic use
  • Child, Preschool
  • Chronic Disease
  • Clinical Trials as Topic
  • Cohort Studies
  • Esophageal Sphincter, Upper* / innervation
  • Esophageal Sphincter, Upper* / physiopathology
  • Evidence-Based Practice*
  • Gastric Acid / chemistry
  • Humans
  • Inflammation / chemically induced
  • Inflammation / pathology
  • Laryngopharyngeal Reflux* / complications
  • Laryngopharyngeal Reflux* / drug therapy
  • Laryngopharyngeal Reflux* / physiopathology
  • Nasal Mucosa / pathology
  • Nasal Surgical Procedures / methods
  • Proton Pump Inhibitors / therapeutic use*
  • Rhinitis* / etiology
  • Rhinitis* / pathology
  • Rhinitis* / physiopathology
  • Rhinitis* / therapy
  • Sinusitis* / etiology
  • Sinusitis* / pathology
  • Sinusitis* / physiopathology
  • Sinusitis* / therapy
  • Treatment Outcome

Substances

  • Anti-Ulcer Agents
  • Proton Pump Inhibitors