What you need to know about bisphosphonates: an overview and general recommendations for orthodontic treatment

J Orthod. 2012 Sep;39(3):186-92. doi: 10.1179/1465312512Z.00000000022.

Abstract

The orthodontic treatment of patients on bisphosphonates is becoming an increasing aspect of contemporary practice. This article will draw attention to the chemical structure and effects of these drugs on bone and will provide the latest recommendations to avoid potential sequelae.

MeSH terms

  • Bisphosphonate-Associated Osteonecrosis of the Jaw / prevention & control*
  • Bone Density Conservation Agents* / administration & dosage
  • Bone Density Conservation Agents* / chemistry
  • Bone Density Conservation Agents* / pharmacokinetics
  • Bone Density Conservation Agents* / pharmacology
  • Bone Remodeling / drug effects
  • Bone and Bones / metabolism
  • Collagen Type I / blood
  • Dental Care for Chronically Ill*
  • Diphosphonates* / administration & dosage
  • Diphosphonates* / chemistry
  • Diphosphonates* / pharmacokinetics
  • Diphosphonates* / pharmacology
  • General Practice, Dental
  • Humans
  • Orthodontics, Corrective*
  • Peptides / blood
  • Practice Guidelines as Topic

Substances

  • Bone Density Conservation Agents
  • Collagen Type I
  • Diphosphonates
  • Peptides
  • collagen type I trimeric cross-linked peptide