Cerebrospinal fluid findings in children with fever-associated status epilepticus: results of the consequences of prolonged febrile seizures (FEBSTAT) study

J Pediatr. 2012 Dec;161(6):1169-71. doi: 10.1016/j.jpeds.2012.08.008. Epub 2012 Sep 14.

Abstract

This prospective multicenter study of 200 patients with fever-associated status epilepticus (FSE), of whom 136 underwent a nontraumatic lumbar puncture, confirms that FSE rarely causes cerebrospinal fluid (CSF) pleocytosis. CSF glucose and protein levels were unremarkable. Temperature, age, seizure focality, and seizure duration did not affect results. CSF pleocytosis should not be attributed to FSE.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biomarkers / cerebrospinal fluid
  • Cerebrospinal Fluid Proteins / metabolism
  • Child
  • Glucose / cerebrospinal fluid
  • Humans
  • Leukocytes / metabolism
  • Leukocytosis / cerebrospinal fluid
  • Leukocytosis / etiology
  • Prospective Studies
  • Seizures, Febrile / cerebrospinal fluid*
  • Seizures, Febrile / physiopathology
  • Spinal Puncture
  • Status Epilepticus / cerebrospinal fluid*
  • Status Epilepticus / etiology

Substances

  • Biomarkers
  • Cerebrospinal Fluid Proteins
  • Glucose