[Indications and use of prothrombin complex in cardiac surgery]

A Pajares; R Vicente; L Larrea; J L Vicente; M Barberá

doi:10.1016/j.redar.2012.02.033

[Indications and use of prothrombin complex in cardiac surgery]

Rev Esp Anestesiol Reanim. 2012 Mar;59(3):150-6. doi: 10.1016/j.redar.2012.02.033. Epub 2012 May 3.

[Article in Spanish]

Authors

A Pajares¹, R Vicente, L Larrea, J L Vicente, M Barberá

Affiliation

¹ Servicio de Anestesiología y Reanimación, Hospital Universitario La Fe, Valencia, España. Electronic address: [email protected].

PMID: 22985756
DOI: 10.1016/j.redar.2012.02.033

Abstract

On of the most common, and serious, complications in cardiac surgery is postoperative bleeding. According to the majority of studies, between 10% and 92% of patients subjected to elective surgery require transfusions of blood products and blood derivatives. Transfusions and reinterventions are associated with longer stays in critical care units and a decrease in survival rates. There have been some important changes in the treatment of changes in haemostasis and post-surgical bleeding in the last few years, particularly with the introduction into clinical practice of working procedures backed up by clinical guidelines, as well as the appearance of new drugs. The aim of this work is to describe the main characteristics and update the use of prothrombin complexes that are currently available in Spain, with special emphasis on their use in cardiac surgery.

Publication types

Review

MeSH terms

Anticoagulants / adverse effects
Blood Coagulation Factors / administration & dosage
Blood Coagulation Factors / adverse effects
Blood Coagulation Factors / economics
Blood Coagulation Factors / supply & distribution
Blood Coagulation Factors / therapeutic use*
Blood Loss, Surgical
Blood-Borne Pathogens
Cardiac Surgical Procedures*
Contraindications
Disease Transmission, Infectious / prevention & control
Drug Contamination
Drug Costs
Heart Diseases / complications
Heart Diseases / surgery
Hemorrhagic Disorders / genetics
Hemostatics / administration & dosage
Hemostatics / adverse effects
Hemostatics / economics
Hemostatics / supply & distribution
Hemostatics / therapeutic use*
Humans
Postoperative Hemorrhage / drug therapy*
Postoperative Hemorrhage / prevention & control
Preanesthetic Medication
Thrombophilia / complications
Thrombophilia / drug therapy
Thrombosis / chemically induced
Vitamin K / antagonists & inhibitors

Substances

Anticoagulants
Blood Coagulation Factors
Hemostatics
Vitamin K
prothrombin complex concentrates