[Thrombotic microangiopathy with anti-ADAMTS 13 antibodies revealing an acute Q fever]

Rev Med Interne. 2012 Nov;33(11):640-2. doi: 10.1016/j.revmed.2012.08.012. Epub 2012 Sep 15.
[Article in French]

Abstract

Introduction: Q fever can commonly mimic systemic diseases, leading to several immunological manifestations. Thrombotic micro-angiopathies manifest as a spectrum of related disorders in the form of thrombocytopenic purpura and hemolytic uremic syndrome.

Case report: We report a 77-year-old woman, who presented an acquired thrombotic microangiopathy with renal expression associated with the presence of anti-ADAMTS 13 antibodies, which occurred during an acute infection by Coxiella burnetii (acute Q fever).

Conclusion: Auto-immune disorders are well-known in chronic or acute Q fever but to our knowledge, this is the first reported observation of thrombotic microangiopathy with anti-ADAMTS 13 antibodies.

Publication types

  • Case Reports

MeSH terms

  • ADAM Proteins / immunology*
  • ADAMTS13 Protein
  • Aged
  • Autoantibodies / blood*
  • Female
  • Humans
  • Q Fever / blood
  • Q Fever / complications*
  • Q Fever / diagnosis*
  • Thrombotic Microangiopathies / blood
  • Thrombotic Microangiopathies / etiology*
  • Thrombotic Microangiopathies / immunology*

Substances

  • Autoantibodies
  • ADAM Proteins
  • ADAMTS13 Protein
  • ADAMTS13 protein, human