Update of faecal markers of inflammation in children with cystic fibrosis

Jung M Lee; Steven T Leach; Tamarah Katz; Andrew S Day; Adam Jaffe; Chee Y Ooi

doi:10.1155/2012/948367

Update of faecal markers of inflammation in children with cystic fibrosis

Mediators Inflamm. 2012:2012:948367. doi: 10.1155/2012/948367. Epub 2012 Aug 21.

Authors

Jung M Lee¹, Steven T Leach, Tamarah Katz, Andrew S Day, Adam Jaffe, Chee Y Ooi

Affiliation

¹ School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, High Street, Sydney, NSW, Australia.

Abstract

There is evidence of intestinal inflammation in patients with CF. Intestinal inflammation may negatively impact the nutritional status of patient with CF, which adversely affects pulmonary function and survival. This paper provides an up-to-date review of intestinal inflammation in CF and an evaluation of utility of two specific faecal inflammatory markers (S100A12 and calprotectin).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers / metabolism*
Cystic Fibrosis / immunology*
Cystic Fibrosis / metabolism*
Feces / chemistry*
Humans
Inflammation / immunology
Inflammation / metabolism*
Leukocyte L1 Antigen Complex / metabolism
S100 Proteins / metabolism
S100A12 Protein

Substances

Biomarkers
Leukocyte L1 Antigen Complex
S100 Proteins
S100A12 Protein
S100A12 protein, human